Severe Pregnancy Complication (Pre-eclampsia)
is associated with greater
periodontal destruction
Pre- eclampsia is a
pregnancy-specific disease which is
one of the leading causes of
maternal and fetal mortality. The
etiology of pre-eclampsia remains
elusive. The underlying pathology
may be related to a generalizad
intravascular hyperinflammatory
state. Since the placental
histopathologic lesions of acute
atherosis, seen in pre-eclampsia,
bear resemblance to those seen in
atherosclerosis, and recent evidence
links atherosclerosis with chronic
infection, the authors decided to
investigate a possible link between
pre-eclampsia and chronic
periodontal infection. Thirty
primigravidas, 15 suffering from
pre-eclampsia, had full mouth
periodontal examination. Gingival
crevicular fluid samples were taken
for laboratory immunological
assessment. Similar examination and
sampling were performed in 15
age-and maternal status-matches
controls.
Results showed that significantly
higher periodontal probing depth and
clinical attachment level scores
were found in the pre-eclamptic
group compared with controls (2.98
versus 2.11 and 3.33 verus 2.30,
respectively). Plaque index,
gingival index, and mean gingival
overgrowth scores were very similar
in both groups. Futhermore,
prostaglandin E2 (PGE2), tumor
necrosis factor (TNF)-, and
interleukin (IL)-1 levels were all
significantly higher in the pre-eclamtic
group (247.4 ngr/sample, vesus 89.1
ngr/sample, 8.03 pgr/sample versus
4.03 pgr/sample, and 175.7pgr/sample
versus 62.2 pgr/sample,
respectively.)
The authors concluded that the above
results suggest a possible
association between periodontal
inflammation and pre-eclampsia.
Oettinger-Barak O., Barak S., et al.
J of Periodontology 2005, vol. 76
(1): 134-7
|
2005-03-30 |
ORAL CANCER
Every hour of every day, one
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According to the American
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These factors increase your
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Heavy or chronic alcohol
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Viral infections,
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Long-term exposure to the
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History of oral leukoplakia
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Early detection saves lives”
– The Oral Cancer Foundation
|
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